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This web page supremo-trial.com states the following, "SUPREMO has now closed to recruitment." We saw that the webpage also stated " We have divided our website into three different areas with different kinds of information to meet your needs." It also said " A patient area where you will find information about the trial if you are a patient taking part, or thinking about whether to take part. An area for potential investigators who are thinking about joining the trial where you can find out more about what is involved." The header had supremo as the highest ranking optimized keyword. It is followed by cancer, trial, and breast which isn't as ranked as highly as supremo. The next words supremo-trial.com used was postoperative. radiotherapy was included but might not be understood by search crawlers.